Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
Unraveling plant natural chemical diversity for drug discovery purposes
E Lautié, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …
benefit from the immense natural chemical diversity is a concern in many laboratories …
Bioactivity-based molecular networking for the discovery of drug leads in natural product bioassay-guided fractionation
LF Nothias, M Nothias-Esposito… - Journal of natural …, 2018 - ACS Publications
It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound (s) may not be isolated …
good bioassay results in the initial extract, the active compound (s) may not be isolated …
A critical review on exploiting the pharmaceutical potential of plant endophytic fungi
The escalating demand for secondary metabolites in international markets poses a severe
threat to many plant species. An unscrupulous collection is also the immediate challenge to …
threat to many plant species. An unscrupulous collection is also the immediate challenge to …
Effect-directed analysis supporting monitoring of aquatic environments—an in-depth overview
Aquatic environments are often contaminated with complex mixtures of chemicals that may
pose a risk to ecosystems and human health. This contamination cannot be addressed with …
pose a risk to ecosystems and human health. This contamination cannot be addressed with …
Botanicals and their bioactive phytochemicals for women's health
BM Dietz, A Hajirahimkhan, TL Dunlap… - Pharmacological reviews, 2016 - ASPET
Botanical dietary supplements are increasingly popular for women's health, particularly for
older women. The specific botanicals women take vary as a function of age. Younger …
older women. The specific botanicals women take vary as a function of age. Younger …
Bioprospecting endophytic fungi from Fusarium genus as sources of bioactive metabolites
RMK Toghueo - Mycology, 2020 - Taylor & Francis
Endophytic fungi became an attractive source for the discovery of new leads, because of the
complexity and the structural diversity of their secondary metabolites. The genus Fusarium …
complexity and the structural diversity of their secondary metabolites. The genus Fusarium …
NMR: unique strengths that enhance modern metabolomics research
Nuclear magnetic resonance (NMR) spectroscopy is an important analytical technique in
metabolomics. Because it provides atomic-level detail of small molecules, NMR is …
metabolomics. Because it provides atomic-level detail of small molecules, NMR is …
Analytical methods for the determination of mixtures of bisphenols and derivatives in human and environmental exposure sources and biological fluids. A review
N Caballero-Casero, L Lunar, S Rubio - Analytica Chimica Acta, 2016 - Elsevier
Bisphenol A (BPA) is ubiquitous in humans and the environment. Its potential adverse
effects through genomic and non-genomic pathways have fostered BPA replacement by …
effects through genomic and non-genomic pathways have fostered BPA replacement by …
Anticancer drug discovery from microbial sources: The unique mangrove streptomycetes
Worldwide cancer incidence and mortality have always been a concern to the community.
The cancer mortality rate has generally declined over the years; however, there is still an …
The cancer mortality rate has generally declined over the years; however, there is still an …