Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers
K Chen, P Lu, NM Beeraka, OA Sukocheva… - Seminars in cancer …, 2022 - Elsevier
Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders
S Jamwal, JK Blackburn, JD Elsworth - Pharmacology & Therapeutics, 2021 - Elsevier
Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …
disorders, characterized by progressive loss of the structure and function of neurons. Current …
[HTML][HTML] Mitochondrial DNA integrity: role in health and disease
As the primary cellular location for respiration and energy production, mitochondria serve in
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …
Causal roles of mitochondrial dynamics in longevity and healthy aging
Mitochondria are organized in the cell in the form of a dynamic, interconnected network.
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …
[HTML][HTML] Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis, import, and assembly pathways
JX Tang, K Thompson, RW Taylor… - International Journal of …, 2020 - mdpi.com
The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …
Mitochondrial DNA: Epigenetics and environment
Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …
[HTML][HTML] Cancer cell metabolism: Rewiring the mitochondrial hub
To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …
[HTML][HTML] Starting the engine of the powerhouse: mitochondrial transcription and beyond
Mitochondria are central hubs for cellular metabolism, coordinating a variety of metabolic
reactions crucial for human health. Mitochondria provide most of the cellular energy via their …
reactions crucial for human health. Mitochondria provide most of the cellular energy via their …
[HTML][HTML] Mitochondrial epigenetics in aging and cardiovascular diseases
Mitochondria are cellular organelles which generate adenosine triphosphate (ATP)
molecules for the maintenance of cellular energy through the oxidative phosphorylation …
molecules for the maintenance of cellular energy through the oxidative phosphorylation …
[HTML][HTML] Mitoepigenetics and its emerging roles in cancer
Z Dong, L Pu, H Cui - Frontiers in cell and developmental biology, 2020 - frontiersin.org
In human beings, there is a∼ 16,569 bp circular mitochondrial DNA (mtDNA) encoding 22
tRNAs, 12S and 16S rRNAs, 13 polypeptides that constitute the central core of ETC/OxPhos …
tRNAs, 12S and 16S rRNAs, 13 polypeptides that constitute the central core of ETC/OxPhos …