Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Chronic kidney disease (CKD) is a public health problem with very high prevalence and
mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient …

Acid-base homeostasis is critical to maintenance of normal health. Renal ammonia
excretion is the quantitatively predominant component of renal net acid excretion, both …

Acute and chronic kidney disease are responsible for large healthcare costs worldwide.
During injury, kidney metabolism undergoes profound modifications in order to adapt to …

Metabolic acidosis, defined as a plasma or serum bicarbonate concentration< 22 mmol/L, is
a frequent consequence of chronic kidney disease (CKD) and occurs in~ 10–30% of …

Distal renal tubular acidosis (dRTA) is a tubular disorder with a primary defect of urinary
acidification and acid excretion in the collecting duct system. Consequently, patients …

The kidneys play a major role in the regulation of acid-base balance by reabsorbing
bicarbonate filtered by the glomeruli and excreting titratable acids and ammonia into the …

Glutamine is the most abundant amino acid in plasma and has numerous roles in the
organism. To fulfil these roles glutamine has to be taken into or released from cells by active …

Acid-base balance is critical for normal life. Acute and chronic disturbances impact cellular
energy metabolism, endocrine signaling, ion channel activity, neuronal activity, and …