Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation

R Bai, C Yao, Z Zhong, J Ge, Z Bai, X Ye, T Xie… - European Journal of …, 2021 - Elsevier
Inflammation is an adaptive response of the immune system to tissue malfunction or
homeostatic imbalance. Corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) …

[HTML][HTML] The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)

A Arcanjo, J Logullo, CCB Menezes… - Scientific reports, 2020 - nature.com
The novel coronavirus SARS-CoV-2 causes COVID-19, a highly pathogenic viral infection
threatening millions. The majority of the individuals infected are asymptomatic or mildly …

Cissampelos genus: biological activities, ethnobotanical and phytochemical aspects

JW da Silva Mendes, WEM Cunha… - Phytochemistry …, 2020 - Springer
Abstract Species of Cissampelos (Menispermaceae) are widely used in folk medicine in
various cultures, for the treatment of a wide variety of diseases. Several ethnobotanical …

The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation

Y Shang, M Coppo, T He, F Ning, L Yu, L Kang… - Nature …, 2016 - nature.com
Most of the known regulatory mechanisms that curb inflammatory gene expression target pre–
transcription-initiation steps, and evidence for post-initiation regulation of inflammatory gene …

[HTML][HTML] Ouabain inhibits p38 activation in mice neutrophils

LHA Cavalcante‑Silva, DCM Carvalho… - …, 2021 - Springer
Ouabain is a cardiac steroid hormone with immunomodulatory effects. It inhibits neutrophils
migration induced by different stimuli, but little is known about the mechanisms involved in …

Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models

IRP De Sales, RDO Formiga, FDF Machado… - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance The leaves and roots of Cissampelos sympodialis
(Menispermaceae) are used by indian tribes and in folk medicine to treat genitourinary …

Phytochemical Constituents and Biological Activities of Plants from the Genus Cissampelos

J He, F Li, X Yan, Q Cheng, R Xue, H Yu… - Chemistry & …, 2021 - Wiley Online Library
Cissampelos is a significant genus comprising of approximately 21 species of the medicinal
plants (Menispermaceae). The plants of this genus are used in traditional medicine for the …

Milonine, a morphinandienone alkaloid, has anti-inflammatory and analgesic effects by inhibiting TNF-α and IL-1β production

LR Silva, AF Alves, LHA Cavalcante-Silva, RM Braga… - Inflammation, 2017 - Springer
Milonine is a morphinandienone alkaloid from Cissampelos sympodialis Eichl
(Menispermaceae), a plant used in Brazil to treat inflammatory disorders. In this study, we …

[HTML][HTML] Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

TD Medeiros, AT Pereira, FS Silva… - Brazilian Journal of …, 2020 - SciELO Brasil
Diabetes Mellitus (DM) is a metabolic syndrome characterized by hyperglycemia. Chronic
complications affect a number of organs, including the lungs. Cissampelos sympodialis Eichl …

Anti-inflammatory Potential of Lead Compounds and Their Derivatives from Medicinal Plants

NS Nirmala, NB Krishnan, V Vivekanandan… - … of Tropical Medicinal …, 2023 - Springer
Inflammation is a double-edged sword that acts against pathogens invasion; whereas
undesirable immune responses caused inflammation/tissue damage leads to autoimmune …