Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …

Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …

Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …

Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were
outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild …

The major metabolic pathway for elimination of cholesterol is via conversion to bile acids. In
addition to this metabolic function, bile acids also act as signaling molecules that negatively …

Infection and inflammation induce the acutephase response (APR), leading to multiple
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …

The estrogen receptor (ER) is a ligand-activated enhancer protein that is a member of the
steroid/nuclear receptor superfamily. Two genes encode mammalian ER: ERα and ERβ. ER …

Nuclear receptors are major targets for drug discovery and have key roles in development
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …

Cryptochromes are blue, ultraviolet-A photoreceptors. They were first characterized for
Arabidopsis and are also found in ferns and algae; they appear to be ubiquitous in the plant …

II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition