Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …

Hypertension (HTN) is present in more than 50% of patients with diabetes mellitus (DM) and
contributes significantly to both microvascular and macrovascular disease in DM (Fig. 1). 1 …

Type 2 diabetes mellitus (T2DM) is characterized by multiple pathophysiologic
abnormalities. With time, multiple glucose-lowering medications are commonly required to …

Аннотация Современная диабетология обращает самое серьезное внимание на
метаболизм жировой ткани потому, что жировая ткань очень тесно связана с …

Glucagon-like peptide 1 receptor (GLP-1R) and glucose-dependent insulinotropic
polypeptide receptor (GIPR) are two class B1 G protein-coupled receptors, which are …

Background—Dipeptidyl-peptidase 4 (DPP-4) inhibitors are increasingly used to accomplish
glycemic targets in patients with type II diabetes mellitus. Because DPP-4 is expressed in …

Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …

Oxyntomodulin (OXM) is a peptide hormone released from the gut in post-prandial state that
activates both the glucagon-like peptide-1 receptor (GLP1R) and the glucagon receptor …

Abstract Dipeptidyl peptidase 4 (DPP-4) inhibitors (commonly referred to as gliptins) are a
novel class of oral antihyperglycaemic agents with demonstrated efficacy in the treatment of …