[HTML][HTML] The tumor microenvironment in tumorigenesis and therapy resistance revisited
Simple Summary Tumors are not masses of cancer cells alone but made up of cancer cells,
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …
Emerging roles of ECM remodeling processes in cancer
Extracellular matrix (ECM) plays a central and dynamic role in the creation of tumor
microenvironment. Herein we discuss the emerging biophysical and biochemical aspects of …
microenvironment. Herein we discuss the emerging biophysical and biochemical aspects of …
Engineering of functional, perfusable 3D microvascular networks on a chip
Generating perfusable 3D microvessels in vitro is an important goal for tissue engineering,
as well as for reliable modelling of blood vessel function. To date, in vitro blood vessel …
as well as for reliable modelling of blood vessel function. To date, in vitro blood vessel …
[HTML][HTML] Flow-induced reprogramming of endothelial cells in atherosclerosis
Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …
artery disease continue to be leading causes of death worldwide despite the success of …
The Mesangial cell—the glomerular stromal cell
Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and
the glomerular response to injury. A growing body of evidence demonstrates that …
the glomerular response to injury. A growing body of evidence demonstrates that …
Role of the extracellular matrix in morphogenesis
HK Kleinman, D Philp, MP Hoffman - Current opinion in biotechnology, 2003 - Elsevier
The extracellular matrix is a complex, dynamic and critical component of all tissues. It
functions as a scaffold for tissue morphogenesis, provides cues for cell proliferation and …
functions as a scaffold for tissue morphogenesis, provides cues for cell proliferation and …
[HTML][HTML] TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism
DW Seo, H Li, L Guedez, PT Wingfield, T Diaz… - Cell, 2003 - cell.com
Tissue inhibitors of metalloproteinases (TIMPs) suppress matrix metalloproteinase (MMP)
activity critical for extracellular matrix turnover associated with both physiologic and …
activity critical for extracellular matrix turnover associated with both physiologic and …
Controlled drug delivery in tissue engineering
The concept of tissue and cell guidance is rapidly evolving as more information regarding
the effect of the microenvironment on cellular function and tissue morphogenesis become …
the effect of the microenvironment on cellular function and tissue morphogenesis become …
Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function
The motility and morphogenesis of endothelial cells is controlled by spatio-temporally
regulated activation of integrin adhesion receptors, and integrin activation is stimulated by …
regulated activation of integrin adhesion receptors, and integrin activation is stimulated by …
CYR61 (CCN1) is essential for placental development and vascular integrity
FE Mo, AG Muntean, CC Chen, DB Stolz… - … and cellular biology, 2002 - Taylor & Francis
CYR61 (CCN1) is a member of the CCN family of secreted matricellular proteins that
includes connective tissue growth factor (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 …
includes connective tissue growth factor (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 …