ECM regulates MT1-MMP localization with β1 or αvβ3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells

BG Gálvez, S Matías-Román, M Yáñez-Mó… - The Journal of cell …, 2002 - rupress.org
Regulation of membrane-type 1 matrix metalloproteinase (MT1-MMP) by different
extracellular matrices (ECMs) on human endothelial cells (ECs) has been investigated. First …

Integrins control motile strategy through a Rho–cofilin pathway

EHJ Danen, J van Rheenen, W Franken… - The Journal of cell …, 2005 - rupress.org
During wound healing, angiogenesis, and tumor invasion, cells often change their
expression profiles of fibronectin-binding integrins. Here, we show that β1 integrins promote …

Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial …

RA Dean, GS Butler, Y Hamma-Kourbali… - … and cellular biology, 2007 - Taylor & Francis
Matrix metalloproteinases (MMPs) exert both pro-and antiangiogenic functions by the
release of cytokines or proteolytically generated angiogenic inhibitors from extracellular …

MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and …

I Keklikoglou, K Hosaka, C Bender, A Bott, C Koerner… - Oncogene, 2015 - nature.com
Recent advances in cancer biology have emerged important roles for microRNAs (miRNAs)
in regulating tumor responses. However, their function in mediating intercellular …

Pathobiology of human cerebrovascular malformations: basic mechanisms and clinical relevance

J Gault, H Sarin, NA Awadallah, R Shenkar… - Neurosurgery, 2004 - journals.lww.com
Abstract CEREBROVASCULAR MALFORMATIONS AFFECT more than 3% of the
population, exposing them to a lifetime risk of hemorrhagic stroke, seizures, and focal …

Angiogenesis-dependent and independent phases of intimal hyperplasia

R Khurana, Z Zhuang, S Bhardwaj, M Murakami… - Circulation, 2004 - Am Heart Assoc
Background—Neointimal vascular smooth muscle cell (VSMC) proliferation is a primary
cause of occlusive vascular disease, including atherosclerosis, restenosis after …

Self-assembling peptides: from bio-inspired materials to bone regeneration

CE Semino - Journal of dental research, 2008 - journals.sagepub.com
In recent years, the development of new biomaterials with specifications for tissue and organ
functional requirements—such as proper biological, structural, and biomechanical …

Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1

I Cascone, L Napione, F Maniero, G Serini… - The Journal of cell …, 2005 - rupress.org
During angiogenic remodeling, Ang-1, the ligand of Tie2 tyrosine kinase, is involved in
vessel sprouting and stabilization through unclear effects on nascent capillaries and mural …

Talin-dependent integrin activation regulates VE-cadherin localization and endothelial cell barrier function

FE Pulous, CM Grimsley-Myers, S Kansal… - Circulation …, 2019 - Am Heart Assoc
Rationale: Endothelial barrier function depends on the proper localization and function of
the adherens junction protein VE (vascular endothelial)-cadherin. Previous studies have …

Integrins in angiogenesis: multitalented molecules in a balancing act

KM Hodivala-Dilke, AR Reynolds, LE Reynolds - Cell and tissue research, 2003 - Springer
Over the last 10–15 years the varied roles of cell adhesion molecules in the development of
new blood vessels have received extensive attention. To date, more than 500 publications …