Angiogenesis is the process of developing vascular sprouts from existing blood vessels.
Luminal endothelial cells convert into “tip” cells that contribute to the development of a …

Developing tissue engineering approaches to generate functional vascular networks is
important for improving treatments of peripheral and cardiovascular disease. Endothelial …

The notion that tumor angiogenesis may have therapeutic implications in the control of tumor
growth was introduced by Dr. Judah Folkman in 1971. The approval of Avastin in 2004 as …

Cells within the vascular wall connect their cytoskeleton to the extracellular matrix (ECM)
through a family of cell surface receptors known as integrins. The ability of integrins to act as …

Advances in our understanding of fundamental biological processes can be made by the
analysis of defects manifested in inherited diseases. The genes responsible for these …

Molecular signals in the form of growth factors are the main modulators of cell behavior.
However, the use of growth factors in tissue engineering has several drawbacks, including …

The vascular endothelium is a cellular interface between the blood and the interstitial space
of tissue, which controls the exchange of fluid, solutes and cells by both transcellular and …

The morphology and function of endothelial cells depends on the physical and chemical
characteristics of the extracellular environment. Here, we designed silicon surfaces on which …

It is now widely accepted that tumor-angiogenesis plays a crucial role in tumor growth, tumor
propagation and metastasis formation. Among several angiogenic activators, the vascular …

We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of
mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely …