Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: evidence for a negative signal delivered through the mannose receptor
J Nigou, C Zelle-Rieser, M Gilleron… - The Journal of …, 2001 - journals.aai.org
IL-12 is a key cytokine in directing the development of type 1 Th cells, which are critical to
eradicate intracellular pathogens such as Mycobacterium tuberculosis. Here, we report that …
eradicate intracellular pathogens such as Mycobacterium tuberculosis. Here, we report that …
Chemokines: agents for the immunotherapy of cancer?
B Homey, A Müller, A Zlotnik - Nature Reviews Immunology, 2002 - nature.com
Chemokines, a superfamilly of small cytokine-like molecules, regulate leukocyte transport in
the body. In recent years, we have witnessed the transition of immunotherapeutic strategies …
the body. In recent years, we have witnessed the transition of immunotherapeutic strategies …
Inflammatory cell infiltration of tumors: Jekyll or Hyde
JE Talmadge, M Donkor, E Scholar - Cancer and Metastasis Reviews, 2007 - Springer
Inflammatory cell infiltration of tumors contributes either positively or negatively to tumor
invasion, growth, metastasis, and patient outcomes, creating a Dr. Jekyll or Mr. Hyde …
invasion, growth, metastasis, and patient outcomes, creating a Dr. Jekyll or Mr. Hyde …
IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men
E Jouanguy, R Döffinger, S Dupuis, A Pallier… - Current opinion in …, 1999 - Elsevier
The development of gene-knockout mice and the identification of gene-deficient humans
have improved our understanding of the role of IL-12 and IFN-γ in host defense. Comparison …
have improved our understanding of the role of IL-12 and IFN-γ in host defense. Comparison …
Mature dendritic cells derived from human monocytes within 48 hours: a novel strategy for dendritic cell differentiation from blood precursors
M Dauer, B Obermaier, J Herten, C Haerle… - The Journal of …, 2003 - journals.aai.org
It is widely believed that generation of mature dendritic cells (DCs) with full T cell stimulatory
capacity from human monocytes in vitro requires 5–7 days of differentiation with GM-CSF …
capacity from human monocytes in vitro requires 5–7 days of differentiation with GM-CSF …
Dendritic cell development and survival require distinct NF-κB subunits
F Ouaaz, J Arron, Y Zheng, Y Choi, AA Beg - Immunity, 2002 - cell.com
Despite the established role of dendritic cells (DCs) in regulating T lymphocyte activation,
intracellular mechanisms responsible for controlling DC function are largely undefined …
intracellular mechanisms responsible for controlling DC function are largely undefined …
Mathematical modeling of tumor-induced angiogenesis
Cancer is a collection of diseases with the common feature of uncontrolled cellular growth.
Most tissues in the body can give rise to cancer, some even yield several types, and each …
Most tissues in the body can give rise to cancer, some even yield several types, and each …
[HTML][HTML] Immunology of IL-12: An update on functional activities and implications for disease
KAM Ullrich, LL Schulze, EM Paap, TM Müller… - EXCLI …, 2020 - ncbi.nlm.nih.gov
As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In
response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and …
response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and …
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs
C Borg, A Jalil, D Laderach, K Maruyama, H Wakasugi… - Blood, 2004 - ashpublications.org
Mature dendritic cells (mDCs) can trigger the effector functions of natural killer (NK) cells.
Knock-out, small-interfering RNA or neutralizing antibodies targeting interleukin 12 (IL-12) …
Knock-out, small-interfering RNA or neutralizing antibodies targeting interleukin 12 (IL-12) …