Therapeutic drug monitoring (TDM) of beta-lactam antibiotics is recommended to address
the variability in exposure observed in critical illness. However, the impact of TDM-guided …

The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global
public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug …

We described ceftriaxone-induced CNS adverse events through the largest case series of
Adverse Drug Reactions (ADRs) reports, from 1995 to 2017, using the French …

Adjusting dosing regimens based on measurements of carbapenem levels may improve
carbapenem exposure in patients. This systematic review aims to describe the effect …

An estimated 70% of critically ill patients receive antibiotics, most frequently beta-lactams.
The pharmacokinetic properties of these substances in this patient population are poorly …

Therapeutic drug monitoring (TDM) and continuous infusion strategies are effective
interventions in clinical practice, but these practices are still largely unknown in Colombia …

Objectives To investigate the factors influencing imipenem/cilastatin (IMI) and meropenem
(MEM) concentrations in critically ill adult patients and the role of these concentrations in the …

Thermal injuries alter pharmacokinetics, complicating the prediction of standard antibiotic
dose effectiveness. Therapeutic drug monitoring (TDM) has been proposed to prevent …

Therapeutic drug monitoring is an important clinical testing of the drugs to monitor their
concentrations in plasma in order to guarantee their optimal impact, and to avoid any side …

Currently, assays for rapid therapeutic drug monitoring (TDM) of β-lactam antibiotics in
blood, which might be of benefit in optimizing doses for treatment of critically ill patients …