Recombinant adeno-associated viruses (AAV) are under intensive investigation in
numerous clinical trials after they have emerged as a highly promising vector for human …

Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted
therapy for cancer that has demonstrated notable potential in clinical applications. However …

Glioblastoma multiforme (GBM) is the most common and lethal brain tumor characterized by
a strongly immunosuppressive tumor microenvironment (TME) that represents a barrier also …

Developing predictive biomarkers that can detect the tipping point before metastasis of
hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To …

Every animal grows from a single fertilized egg into an intricate network of cell types and
organ systems. This process is captured in a lineage tree: a diagram of every cell's ancestry …

Synthetic biology continues to progress by relying on more robust tools for transcriptional
control, of which promoters are the most fundamental component. Numerous studies have …

Copy number variants (CNVs) are regions of the genome that vary in integer copy number.
CNVs, which comprise both amplifications and deletions of DNA sequence, have been …

In biomedical sciences, the function of a protein of interest is investigated by altering its net
activity and assessing the consequences for the cell or organism. To change the activity of a …

Endogenous pancreatic β cell regeneration is a potential strategy for β cell expansion or
neogenesis to treat diabetes. Regeneration can occur through stimulation of existing β cell …

Designing promoters with desirable properties is essential in synthetic biology. Human
experts are skilled at identifying strong explicit patterns in small samples, while deep …