Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period
D Ao, X He, J Liu, L Xu - Signal Transduction and Targeted Therapy, 2023 - nature.com
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted
in significant casualties and put immense strain on public health systems worldwide, leading …
in significant casualties and put immense strain on public health systems worldwide, leading …
Recent advances in SARS-CoV-2 main protease inhibitors: from nirmatrelvir to future perspectives
A Citarella, A Dimasi, D Moi, D Passarella, A Scala… - Biomolecules, 2023 - mdpi.com
The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …
Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitors
Abstract Coronavirus disease 2019 (COVID-19) is a recent pandemic that caused serious
global emergency. To identify new and effective therapeutics, we employed a drug …
global emergency. To identify new and effective therapeutics, we employed a drug …
Drugs for COVID-19: An update
J Ceramella, D Iacopetta, MS Sinicropi, I Andreu… - Molecules, 2022 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the seventh
known human coronavirus, and it was identified in Wuhan, Hubei province, China, in 2020. It …
known human coronavirus, and it was identified in Wuhan, Hubei province, China, in 2020. It …
Potency of Xanthone Derivatives from Garcinia mangostana L. for COVID-19 Treatment through Angiotensin-Converting Enzyme 2 and Main Protease Blockade: A …
C Suhandi, SS Alfathonah, AN Hasanah - Molecules, 2023 - mdpi.com
ACE2 and Mpro in the pathology of SARS-CoV-2 show great potential in developing COVID-
19 drugs as therapeutic targets, due to their roles as the “gate” of viral entry and viral …
19 drugs as therapeutic targets, due to their roles as the “gate” of viral entry and viral …
Complexation of Bromelain, Ficin, and Papain with the Graft Copolymer of Carboxymethyl Cellulose Sodium Salt and N-Vinylimidazole Enhances Enzyme Proteolytic …
AV Sorokin, SS Goncharova, MS Lavlinskaya… - International Journal of …, 2023 - mdpi.com
This study investigates the features of interactions between cysteine proteases (bromelain,
ficin, and papain) and a graft copolymer of carboxymethyl cellulose sodium salt with N …
ficin, and papain) and a graft copolymer of carboxymethyl cellulose sodium salt with N …
Sweet Basil (Ocimum basilicum L.)―A Review of Its Botany, Phytochemistry, Pharmacological Activities, and Biotechnological Development
An urgent demand for natural compound alternatives to conventional medications has
arisen due to global health challenges, such as drug resistance and the adverse effects …
arisen due to global health challenges, such as drug resistance and the adverse effects …
Green and efficient one-pot three-component synthesis of novel drug-like furo [2, 3-d] pyrimidines as potential active site inhibitors and putative allosteric hotspots …
H Mousavi, B Zeynizadeh, M Rimaz - Bioorganic Chemistry, 2023 - Elsevier
In this paper, an environmentally benign, convenient, and efficient one-pot three-component
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …
Analyzing 3D structures of the SARS-CoV-2 main protease reveals structural features of ligand binding for COVID-19 drug discovery
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) main protease has an
essential role in viral replication and has become a major target for coronavirus 2019 …
essential role in viral replication and has become a major target for coronavirus 2019 …
Discovery and characterization of the covalent SARS-CoV-2 3CLpro inhibitors from Ginkgo biloba extract via integrating chemoproteomic and biochemical …
YN Zhang, GH Zhu, W Liu, Y Xiong, Q Hu, XY Zhuang… - Phytomedicine, 2023 - Elsevier
Background The 3C-like proteases (3CL pro s) are cysteine-rich homodimeric proteins and
can be covalently modified by numerous natural and synthetic compounds, which in turn …
can be covalently modified by numerous natural and synthetic compounds, which in turn …