Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling

L Zhao, HL Ciallella, LM Aleksunes, H Zhu - Drug discovery today, 2020 - Elsevier
Highlights•Drug discovery has been advanced to a big data era with a large amount of
public data sources available.•Ten V features (volume, velocity, variety, veracity, validity …

Synthetic scaffolds for 3D cell cultures and organoids: applications in regenerative medicine

A Marchini, F Gelain - Critical reviews in biotechnology, 2022 - Taylor & Francis
Abstract Three-dimensional (3D) cell cultures offer an unparalleled platform to recreate
spatial arrangements of cells in vitro. 3D cell culture systems have gained increasing interest …

Gastrointestinal organs and organoids-on-a-chip: advances and translation into the clinics

MR Carvalho, LP Yan, B Li, CH Zhang, YL He… - …, 2023 - iopscience.iop.org
Microfluidic organs and organoids-on-a-chip models of human gastrointestinal systems
have been established to recreate adequate microenvironments to study physiology and …

Using 3D in vitro cell culture models in anti-cancer drug discovery

SA Langhans - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
Introduction The high failure rate in drug discovery remains a costly and time-consuming
challenge. Improving the odds of success in the early steps of drug development requires …

[HTML][HTML] Emerging microfluidics for the modeling and treatment of arthritis

N Yang, C Sun, C Dong, Y Huang, Y Zhu, Z Gu - Engineered Regeneration, 2024 - Elsevier
Microfluidic is a technology that allows the precise control of fluid in a micro-channel. With its
advantages of high throughput and low cost, microfluidic technology has achieved good …

Microfluidic systems for assisted reproductive technologies: Advantages and potential applications

RC Sequeira, T Criswell, A Atala, JJ Yoo - Tissue engineering and …, 2020 - Springer
Microfluidic technologies have emerged as a powerful tool that can closely replicate the in-
vivo physiological conditions of organ systems. Assisted reproductive technology (ART) …

Current applications of intestinal organoids: a review

T Xiang, J Wang, H Li - Stem Cell Research & Therapy, 2024 - Springer
In the past decade, intestinal organoid technology has paved the way for reproducing tissue
or organ morphogenesis during intestinal physiological processes in vitro and studying the …

Microhole fiber-optic sensors for nanoliter liquid measurement

Y Tian, G Xiao, Y Luo, J Zhang, L Yuan - Optical Fiber Technology, 2022 - Elsevier
This article reviews the development of nanoliter liquid sensors based on microhole fiber. To
measure liquid characteristics in microscale is crucial in the field of environmental pollution …

Construction of a microfluidic platform with core-shell CdSSe@ ZnS quantum dot-encoded superparamagnetic iron oxide microspheres for screening and locating …

Y Tao, M Pan, F Zhu, Q Liu, P Wang - Frontiers in Nutrition, 2022 - frontiersin.org
The microfluidic platform is a versatile tool for screening and locating bioactive molecules
from functional foods. Here, a layer-by-layer assembly approach was used to fabricate core …

Programmed Internal Reconfigurations in a 3D-Printed Auxetic Metamaterial Enable Fluidic Control for a Vertically Stacked Valve Array

T Supakar, D Space, S Meija, RY Tan, JR Alston… - arXiv preprint arXiv …, 2023 - arxiv.org
Microfluidic valves play a key role within microfluidic systems by regulating fluid flow through
distinct microchannels, enabling many advanced applications in medical diagnostics, lab-on …