From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses

N Kirtipal, S Bharadwaj, SG Kang - Infection, Genetics and Evolution, 2020 - Elsevier
Abstract Human Coronaviruses (HCoV), periodically emerging across the world, are
potential threat to humans such as severe acute respiratory syndrome coronavirus-2 (SARS …

[HTML][HTML] Complosome—the intracellular complement system

EE West, C Kemper - Nature Reviews Nephrology, 2023 - nature.com
The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis

LE Gralinski, TP Sheahan, TE Morrison, VD Menachery… - MBio, 2018 - Am Soc Microbiol
Acute respiratory distress syndrome (ARDS) is immune-driven pathologies that are
observed in severe cases of severe acute respiratory syndrome coronavirus (SARS-CoV) …

[HTML][HTML] The immune response and immunopathology of COVID-19

E Mortaz, P Tabarsi, M Varahram, G Folkerts… - Frontiers in …, 2020 - frontiersin.org
Coronaviruses were first discovered in the 1960s and are named due to their crown-like
shape. Sometimes, but not often, a coronavirus can infect both animals and humans. An …

[HTML][HTML] COVID-19: what has been learned and to be learned about the novel coronavirus disease

Y Yi, PNP Lagniton, S Ye, E Li… - International journal of …, 2020 - ncbi.nlm.nih.gov
The outbreak of Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome (SARS) coronavirus 2 (SARS-CoV-2), has thus far killed over 3,000 people and …

The next generation of therapeutics for chronic kidney disease

MD Breyer, K Susztak - Nature reviews Drug discovery, 2016 - nature.com
Chronic kidney disease (CKD) represents a leading cause of death in the United States.
There is no cure for this disease, with current treatment strategies relying on blood pressure …

[HTML][HTML] ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious …

KL Winthrop, X Mariette, JT Silva, E Benamu… - Clinical Microbiology …, 2018 - Elsevier
Background The present review is part of the ESCMID Study Group for Infections in
Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and …

Activation and regulation of alloreactive T cell immunity in solid organ transplantation

C Duneton, PD Winterberg, ML Ford - Nature Reviews Nephrology, 2022 - nature.com
Transplantation is the only curative treatment for patients with kidney failure but it poses
unique immunological challenges that must be overcome to prevent allograft rejection and …

[HTML][HTML] The role of the complement system in traumatic brain injury: a review

A Hammad, L Westacott, M Zaben - Journal of neuroinflammation, 2018 - Springer
Traumatic brain injury (TBI) is an important cause of disability and mortality in the western
world. While the initial injury sustained results in damage, it is the subsequent secondary …

[HTML][HTML] Drug-induced thrombotic microangiopathy: an updated review of causative drugs, pathophysiology, and management

T Mazzierli, F Allegretta, E Maffini… - Frontiers in …, 2023 - frontiersin.org
Drug-induced thrombotic microangiopathy (DITMA) represents 10%–13% of all thrombotic
microangiopathy (TMA) cases and about 20%–30% of secondary TMAs, just behind …