All mammalian eggs are surrounded by a relatively thick extracellular coat, the zona
pellucida, that plays vital roles during oogenesis, fertilization, and preimplantation …

Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …

All mammalian oocytes and eggs are surrounded by a relatively thick extracellular matrix
(ECM), the zona pellucida (ZP), that plays vital roles during oogenesis, fertilization, and …

The human zona pellucida (ZP) is an extracellular glycoprotein matrix composed of ZP1,
ZP2, ZP3, and ZP4 surrounding the oocyte, and it plays an important role in sperm–egg …

The zona pellucida (ZP) is a specialized extracellular coat that surrounds the plasma
membrane of mammalian eggs. Its presence is essential for successful completion of …

Cytosine base editing achieves C• G-to-T• A substitutions and can convert four codons
(CAA/CAG/CGA/TGG) into STOP-codons (induction of STOP-codons, iSTOP) to knock out …

Premature ovarian failure (POF) is a disorder of multicausal etiology leading to infertility in
women. Development of ovarian auto-antibodies is a causative factor in most POF cases …

Mammalian fertilisation begins when sperm interacts with the egg zona pellucida (ZP),
whose ZP1 subunit is important for fertility by covalently cross-linking ZP filaments into a …

One of the biggest prerequisites for pregnancy is the fertilization step, where a human
haploid spermatozoon interacts and penetrates one haploid oocyte in order to produce the …

An early step in mammalian fertilization is species‐restricted binding of sperm to the egg's
zona pellucida (ZP), a thick extracellular coat that surrounds eggs. Sperm bind to the ZP of …