Antigen processing and presentation are the cornerstones of adaptive immunity. B cells
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …

The presentation of exogenous antigens on MHC class I molecules, known as cross-
presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

The liver is a unique anatomical and immunological site in which antigen‐rich blood from
the gastrointestinal tract is pressed through a network of sinusoids and scanned by antigen …

▪ Abstract The conversion of exogenous and endogenous proteins into immunogenic
peptides recognized by T lymphocytes involves a series of proteolytic and other enzymatic …

Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility
complex (MHC) I complexes from antigens they have collected from cells in tissues and …

The principal components of both MHC class I and class II antigen processing and
presentation pathways are well known. In dendritic cells, these pathways are tightly …

As a population, dendritic cells (DC s) appear to be the best cross‐presenters of internalized
antigens on major histocompatibility complex class I molecules in the mouse. To do this, DC …

The innate immune system provides many ways to quickly resist infection. The twobest-
studieddefenses indendritic cells (DCs) are the productionof protective cytokines—like …

Dendritic cells (DCs) comprise several subsets, and their roles in the presentation of
antigens derived from pathogens, vaccines and self tissues are now beginning to be …