In the past decade, nonalcoholic fatty liver disease (NAFLD) has become a leading cause of
chronic liver disease and cirrhosis, as well as an important risk factor for hepatocellular …

Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …

Cirrhosis is a multisystemic disease wherein inflammatory responses originating from
advanced liver disease and its sequelae affect distant compartments. Patients with cirrhosis …

Background: Microplastics (MPs) are small particles of plastic (≤ 5 mm in diameter). In
recent years, oral exposure to MPs in living organisms has been a cause of concern. Leaky …

Tissue injury and inflammatory response trigger the development of fibrosis in various
diseases. It has been recognized that both innate and adaptive immune cells are important …

Viral infections cause substantial human morbidity and mortality, and are a significant health
burden worldwide. Following a viral infection, the host may initiate complex antiviral immune …

Gut dysbiosis has been reported in chronic hepatitis B (CHB) infection, however its role in
CHB progression and antiviral treatment remains to be clarified. Herein, the present study …

The liver is a lymphoid organ with unique immunological properties, particularly, its
predominant innate immune system. The balance between immune tolerance and immune …

Tissue-resident lymphocytes usually reside in barrier sites and are involved in innate and
adaptive immunity. In recent years, many studies have shown that multiple types of …

Tissue-resident immune cells reside in distinct niches across organs, where they contribute
to tissue homeostasis and rapidly respond to perturbations in the local microenvironment …