Background The development of systemic treatment options leveraging the molecular
landscape of advanced thyroid cancer is a burgeoning field. This is a multidisciplinary …

Highlights•New selective RET inhibitors have activity and favourable toxicity profiles in RET-
altered solid tumours.•There is a need to identify the optimal techniques to detect RET …

The use of immunohistochemistry cannot be underestimated in the everyday practice of
thyroid pathology. It has evolved over the years beyond the traditional confirmation of thyroid …

The ETV6-NTRK3 translocation characterizes a subset of radiation associated and pediatric
papillary thyroid carcinomas (PTCs). We now describe the clinicopathologic features of …

The application of immunohistochemistry to the diagnosis of thyroid lesions has increased
as new biomarkers have emerged. In this review, we discuss the biomarkers that are critical …

Simple Summary Over the past three decades, the incidence of thyroid cancer has been
rising, with 90% being the well-differentiated thyroid cancer subtype. After diagnosis and …

In many laboratories, immunohistochemistry (IHC) has become a routine supplement to the
classic morphologic approach of investigational pathology. The specificity of the IHC test is …

Carcinoma of unknown primary (CUP) is a heterogeneous group of metastatic cancers in
which the site of origin is not identifiable. These carcinomas have a poor outcome due to …

In the setting of pronounced inflammation, changes in the epithelium may overlap with
neoplasia, often rendering it impossible to establish a diagnosis with certainty in daily …

Background Though the management of malignancies has improved vastly in recent years,
many treatment options lack the desired efficacy and fail to adequately augment patient …