Gastric cancer is in decline in most developed countries; however, it still accounts for a
notable fraction of global mortality and morbidity related to cancer. High-throughput methods …

Glioblastoma (GBM) is the most common and malignant type of primary brain tumor,
showing rapid development and resistance to therapies. On average, patients survive 14.6 …

Background DNA hypermethylation is a key epigenetic mechanism for the silencing of many
genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce …

Although gastric cancer (GC) is highly prevalent in China and is a leading cause of cancer-
related death, major advances in early diagnostic and effective therapeutic strategies have …

The silencing of the tumor suppressor gene O-6-methylguanine-DNA methyltransferase
(MGMT) by promoter methylation commonly occurs in human cancers. The relationship …

Background/Aims: Human mutL homolog 1 (MLH1) promoter methylation was reported in
gastric cancer (GC). This study determined the clinicopathological, prognostic, and …

DNA repair mechanism is a process through which the cell repairs its damaged DNA.
Although there are several mechanisms involved in the DNA repair mechanisms, the direct …

Beckground: The association of MGMT (O 6-methyguanine deoxyribonucleic acid
methyltransferase) promoter hypermethylation with gastric cancer (GC) risk has been …

The DNA mismatch repair (MMR) gene MutL homolog 1 (MLH1) is critical for the
maintenance of genomic integrity. Methylation of the MLH1 gene promoter was identified as …

Background: Human mutL homolog 1 (hMLH1) is located on chromosome 3q21-23. As a
classic tumor suppressor gene, many researchers have studied the association between …