Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies

I Lurje, NT Gaisa, R Weiskirchen, F Tacke - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Myofibroblasts: function, formation, and scope of molecular therapies for skin fibrosis

Y Tai, EL Woods, J Dally, D Kong, R Steadman… - Biomolecules, 2021 - mdpi.com
Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis

S Bolourani, M Brenner, P Wang - Journal of Molecular Medicine, 2021 - Springer
Pulmonary fibrosis is a chronic debilitating condition characterized by progressive
deposition of connective tissue, leading to a steady restriction of lung elasticity, a decline in …

Promising biomarkers of radiation-induced lung injury: a review

X Liu, C Shao, J Fu - Biomedicines, 2021 - mdpi.com
Radiation-induced lung injury (RILI) is one of the main dose-limiting side effects in patients
with thoracic cancer during radiotherapy. No reliable predictors or accurate risk models are …

[HTML][HTML] Mechanical feed-forward loops contribute to idiopathic pulmonary fibrosis

MAT Freeberg, A Perelas, JK Rebman… - The American Journal of …, 2021 - Elsevier
Idiopathic pulmonary fibrosis is a progressive scarring disease characterized by
extracellular matrix accumulation and altered mechanical properties of lung tissue. Recent …

The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance

P Spagnolo, R Tonelli, AV Samarelli… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unknown origin
characterized by progressive scarring of the lung leading to irreversible loss of function …

[HTML][HTML] Pansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis

E Xing, F Ma, R Wasikowski, AC Billi… - JCI insight, 2023 - ncbi.nlm.nih.gov
Pansclerotic morphea (PSM) is a rare, devastating disease characterized by extensive soft
tissue fibrosis, secondary contractions, and significant morbidity. PSM pathogenesis is …

[HTML][HTML] Comprehensive review of potential drugs with anti-pulmonary fibrosis properties

J Ma, G Li, H Wang, C Mo - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Pulmonary fibrosis is a chronic and progressive lung disease characterized by the
accumulation of scar tissue in the lungs, which leads to impaired lung function and reduced …

Danshensu alleviates bleomycin-induced pulmonary fibrosis by inhibiting lung fibroblast-to-myofibroblast transition via the MEK/ERK signaling pathway

H Liu, X Zhang, Y Shao, X Lin, F Dong, X Liu - Bioengineered, 2021 - Taylor & Francis
Pulmonary fibrosis (PF) is a chronic pulmonary interstitial disease, and its pathological
process is closely related to fibroblast–myofibroblast differentiation. Danshensu (DSS) has …

Exosomal micro-RNAs as intercellular communicators in idiopathic pulmonary fibrosis

MC Negrete-García… - International Journal of …, 2022 - mdpi.com
Communication between neighboring or distant cells is made through a complex network
that includes extracellular vesicles (EVs). Exosomes, which are a subgroup of EVs, are …