Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …

Apoptosis is a highly-regulated, active process of cell death involved in development,
homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as …

Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …

Objective Chondrocyte apoptosis has also been strongly correlated with the severity of
cartilage damage and matrix depletion in an osteoarthritis (OA) joint. Therefore …

Mitochondria are important regulators of cellular function and survival that may have a key
role in aging-related diseases. Mitochondrial DNA (mtDNA) mutations and oxidative …

Temporomandibular joint (TMJ) osteoarthritis is a common chronic degenerative disease of
the TMJ. In order to explore its aetiology and pathological mechanism, many animal models …

Osteoarthritis is often a progressive and disabling disease, which occurs in the setting of a
variety of risk factors–such as advancing age, obesity, and trauma–that conspire to incite a …

Aging and inflammation are major contributing factors to the development and progression
of arthritic and musculoskeletal diseases.“Inflammaging” refers to low-grade inflammation …

Osteoarthritis (OA) is the most common cause of arthritis and represents an enormous
healthcare burden in industrialized societies. Current therapeutic approaches for OA are …