Genomic insights into ayurvedic and western approaches to personalized medicine
Ayurveda, an ancient Indian system of medicine documented and practised since 1500 BC,
follows a systems approach that has interesting parallels with contemporary personalized …
follows a systems approach that has interesting parallels with contemporary personalized …
Hypoxia-inducible factor (HIF) as a pharmacological target for prevention and treatment of infectious diseases
T Bhandari, V Nizet - Infectious diseases and therapy, 2014 - Springer
In the present era of ever-increasing antibiotic resistance and increasingly complex and
immunosuppressed patient populations, physicians and scientists are seeking novel …
immunosuppressed patient populations, physicians and scientists are seeking novel …
Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible …
JS Debenham, C Madsen-Duggan… - Journal of medicinal …, 2016 - ACS Publications
The discovery of novel 4-hydroxy-2-(heterocyclic) pyrimidine-5-carboxamide inhibitors of
hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) is described. These are potent …
hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) is described. These are potent …
Efficacy and safety of daprodustat for anemia therapy in chronic kidney disease patients: a systematic review and meta-analysis
Q Zheng, Y Wang, H Yang, L Sun, X Fu… - Frontiers in …, 2021 - frontiersin.org
Objective: Daprodustat is a novel oral agent in treating anemia of chronic kidney disease
(CKD), and several clinical trials have been conducted to compare daprodustat with …
(CKD), and several clinical trials have been conducted to compare daprodustat with …
[HTML][HTML] PD-1 and PD-L1 expression in 132 recurrent nasopharyngeal carcinoma: the correlation with anemia and outcomes
Y Zhou, J Miao, H Wu, H Tang, J Kuang, X Zhou… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The expression of Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) has
been reported to be reliable prognostic factors in various malignances including primary …
been reported to be reliable prognostic factors in various malignances including primary …
Oxygen stress: impact on innate immune system, antioxidant defence system and expression of HIF-1α and ATPase 6 genes in Catla catla
Abstract Catla catla catla (2.28±0.1 g) were exposed to six different levels of dissolved
oxygen: 1 (DO-1), 3 (DO-3), 5 (DO-5), 7 (DO-7), 9 (DO-9) and 11 (DO-11) mg/L. DO-5 served …
oxygen: 1 (DO-1), 3 (DO-3), 5 (DO-5), 7 (DO-7), 9 (DO-9) and 11 (DO-11) mg/L. DO-5 served …
Automated sample preparation for the detection and confirmation of hypoxia‐inducible factor stabilizers in urine
L De Wilde, K Roels, K Deventer… - Biomedical …, 2021 - Wiley Online Library
As hypoxia‐inducible factor stabilizers (HIFs) can artificially enhance an athlete's
erythropoiesis, the World Anti‐Doping Agency prohibits their use at all times. Every urine …
erythropoiesis, the World Anti‐Doping Agency prohibits their use at all times. Every urine …
A genetically encoded FRET sensor for hypoxia and prolyl hydroxylases
Oxygen is vital for all aerobic life forms. Oxygen-dependent hydroxylation of hypoxia-
inducible factor (HIF)-1α by prolyl hydroxylase domain enzymes (PHDs) is an important step …
inducible factor (HIF)-1α by prolyl hydroxylase domain enzymes (PHDs) is an important step …
[HTML][HTML] Elevated Levels of Gonadotrophic Hormones and Antioxidant Biomarker in Male Rats Following Administration of Hydromethanol Leaf Extract of Justicia …
SK Mobisson, UL Iyanyi, BE Ehigiator… - Journal of Human …, 2024 - journals.lww.com
Background: 2, 4-Dinitrophenylhydrazine induces testicular toxicity and can result in
reproductive dysfunction in male rats. Aim: This study investigated the effects of …
reproductive dysfunction in male rats. Aim: This study investigated the effects of …
Studies on novel HIF activators, A-503451s.
Y Hirota-Takahata, H Kobayashi, M Kizuka… - The Journal of …, 2016 - nature.com
In the course of our screening for activators of hypoxia-inducible factor (HIF), A-503451 A
and virantmycin were isolated from the cultured broth of an actinomycete strain …
and virantmycin were isolated from the cultured broth of an actinomycete strain …