Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide, as it affects up to 30% of adults in Western countries. Moreover, NAFLD is also …

Chronic inflammation remains an essential complication in the pathogenesis and
aggravation of metabolic diseases. There is a growing interest in the use of medicinal plants …

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with various contributing
factors including genetics, epigenetics, environment and lifestyle such as diet. The hallmarks …

Doxorubicin is a highly effective, first line chemotherapeutic agent used in the management
of hematological and solid tumors. The effective use of doxorubicin in cancer therapy has …

Cardiovascular diseases are the main cause of mortality and morbidity in the world.
Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart …

Isoorientin is a natural C-glucosyl flavone that is generating a lot of interest due to its
multiple pharmacological activities. Increasing experimental data have shown that the robust …

Diabetic patients are at an increased risk of developing heart failure when compared to their
non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be …

Forkhead box protein O1 (FOXO1), a nuclear transcription factor, is preferably activated in
the myocardium of diabetic mice. However, its role and mechanism in the development of …

We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE)
reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells …

Aspalathin is a C-glucosyl dihydrochalcone that is abundantly present in Aspalathus
linearis. This endemic South African plant, belonging to the Cape Floristic region, is normally …