Structure-activity relationships for metal-labeled blood flow tracers: comparison of keto aldehyde bis (thiosemicarbazonato) copper (II) derivatives
EK John, MA Green - Journal of medicinal chemistry, 1990 - ACS Publications
Radiocopper-labeled pyruvaldehyde bis (N4-methylthiosemicarbazonato) copper (II), Cu
[PTSM], is under investigation as a radiopharmaceutical for evaluation of regional blood flow …
[PTSM], is under investigation as a radiopharmaceutical for evaluation of regional blood flow …
A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis (thiosemicarbazonato) copper (ii) complex that binds to amyloid-β plaques
SC Lim, BM Paterson, MT Fodero-Tavoletti… - Chemical …, 2010 - pubs.rsc.org
A bis (thiosemicarbazonato) copper (II) complex with an appended stilbene functional group
binds to amyloid-β plaques that are associated with Alzheimer's disease. The complex has …
binds to amyloid-β plaques that are associated with Alzheimer's disease. The complex has …
[PDF][PDF] A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals
Y Fujibayashi, K Matsumoto, Y Yonekura… - Journal of nuclear …, 1989 - Soc Nuclear Med
A New Zinc-62/Copper-62 Generator for PET Radiopharmaceuticals Page 1 he zinc-62-copper-62
(62Zn-62Cu)[62Zn:T½= 9.2 hr, 62Cu:T½= 9.8 mm, (1)] generator system is consid ered to …
(62Zn-62Cu)[62Zn:T½= 9.2 hr, 62Cu:T½= 9.8 mm, (1)] generator system is consid ered to …
Modification of biodistribution and brain uptake of copper bis (thiosemicarbazonato) complexes by the incorporation of amine and polyamine functional groups
BM Paterson, C Cullinane, PJ Crouch… - Inorganic …, 2019 - ACS Publications
The synthesis of new bis (thiosemicarbazonato) copper (II) complexes featuring polyamine
substituents via selective transamination reactions is presented. Polyamines of different …
substituents via selective transamination reactions is presented. Polyamines of different …
PET imaging of cardiac hypoxia: opportunities and challenges
Myocardial hypoxia is a major factor in the pathology of cardiac ischemia and myocardial
infarction. Hypoxia also occurs in microvascular disease and cardiac hypertrophy, and is …
infarction. Hypoxia also occurs in microvascular disease and cardiac hypertrophy, and is …
[PDF][PDF] Performance of a 62Zn/62Cu generator in clinical trials of PET perfusion agent 62Cu-PTSM
NG Haynes, JL Lacy, N Nayak, CS Martin… - Journal of Nuclear …, 2000 - Soc Nuclear Med
NaOAc) and 1 mL ligandsolution (2 ppm PTSM, 2% EtOH) passingftthroughaseptumintoa35-
ccsyringepr@ oadedwfth28mL stenlewater. This solutionis thoroughlymixed by agitationof …
ccsyringepr@ oadedwfth28mL stenlewater. This solutionis thoroughlymixed by agitationof …
[PDF][PDF] Evaluation of a potential generator-produced PET tracer for cerebral perfusion imaging: single-pass cerebral extraction measurements and imaging with …
CJ Mathias, MJ Welch, ME Raichle… - Journal of Nuclear …, 1990 - Soc Nuclear Med
Department ofRadiology, Washington University School ofMedicine, St. Louis, Missouri;
MURR University ofMissouri, Columbia, Missouri; and School ofPharmacy, Purdue …
MURR University ofMissouri, Columbia, Missouri; and School ofPharmacy, Purdue …
[HTML][HTML] Therapy and diagnosis of Alzheimer's disease: from discrete metal complexes to metal–organic frameworks
A García-García, S Rojas… - Journal of Materials …, 2023 - pubs.rsc.org
Alzheimer's disease (AD) is a neurodegenerative disorder affecting 44 million people
worldwide. Although many issues (pathogenesis, genetics, clinical features, and …
worldwide. Although many issues (pathogenesis, genetics, clinical features, and …
An overview of copper radionuclides and production of 61Cu by proton irradiation of natZn at a medical cyclotron
P Rowshanfarzad, M Sabet, AR Jalilian… - Applied Radiation and …, 2006 - Elsevier
In this article, production methods and applications of copper radionuclides are overviewed
with special attention toward 61Cu, due to its interesting nuclear properties. Selection of …
with special attention toward 61Cu, due to its interesting nuclear properties. Selection of …
In Vitro and In Vivo Evaluation of Bifunctional Bisthiosemicarbazone 64Cu-Complexes for the Positron Emission Tomography Imaging of Hypoxia
PD Bonnitcha, AL Va̅vere, JS Lewis… - Journal of medicinal …, 2008 - ACS Publications
The copper (II) bisthiosemicarbazonato complex, copper-diacetyl-bis (N 4-
methylthiosemicarbazonate)(Cu-ATSM), has been used clinically as a positron emission …
methylthiosemicarbazonate)(Cu-ATSM), has been used clinically as a positron emission …