In their infection cycle, malaria parasites undergo replication and population expansions
within the vertebrate host and the mosquito vector. Host infection initiates with sporozoite …

Lipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in
regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and …

The Plasmodium liver stage is an attractive target for the development of antimalarial drugs
and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a …

Plasmodium falciparum (Pf) parasite development in liver represents the initial step of the
life-cycle in the human host after a Pf-infected mosquito bite. While an attractive stage for life …

The development of therapies and vaccines for human hepatropic pathogens requires
robust model systems that enable the study of host-pathogen interactions. However, in vitro …

In regions of high rates of malaria transmission, mosquitoes repeatedly transmit liver-tropic
Plasmodium sporozoites to individuals who already have blood-stage parasitemia. This …

Malaria infection involves an obligatory, yet clinically silent liver stage,. Hepatocytes operate
in repeating units termed lobules, exhibiting heterogeneous gene expression patterns along …

Plasmodium parasites are transmitted by Anopheles mosquitoes to the mammalian host and
actively infect hepatocytes after passive transport in the bloodstream to the liver. In their …

Pathogens have evolved strategies to promote their survival by dramatically modifying the
transcriptional profile and protein content of the host cells they infect. Modifications of the …

The first obligatory phase of mammalian infection by Plasmodium parasites, the causative
agents of malaria, occurs in the liver of the host. This stage of Plasmodium infection bears …