Many eukaryotic developmental and cell fate decisions that are effected post-
transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In …

Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions
of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this …

Plasmodium parasites undergo an obligatory and asymptomatic developmental stage within
the liver before infecting red blood cells to cause malaria. The hijacked host pathways …

RNA silencing plays a major role in innate antiviral and antibacterial defenses in plants,
insects, and animals through the action of microRNAs (miRNAs). miRNAs can act in favor of …

The first, obligatory replication phase of malaria parasite infections is characterized by rapid
expansion and differentiation of single parasites in liver cells, resulting in the formation and …

One of the attractive properties of artemisinins is their extremely fast-killing capability, quickly
relieving malaria symptoms. Nevertheless, the unique benefits of these medicines are now …

A vaccine to reduce human suffering caused by malarial parasites has been the holy grail of
malaria research. Early studies in the 1940's indicated that attenuated parasites could …

Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that
initiate blood-stage disease. The hepatocyte molecular pathways that permit or abrogate …

Recent studies of liver stage malaria parasite-host interactions have provided exciting new
insights on the cross-talk between parasite and its mammalian (predominantly rodent) host …

Malaria imposes a horrific public health burden–hundreds of millions of infections and
millions of deaths–on large parts of the world. While this unacceptable health burden and its …