During vertebrate infection, obligate intracellular malaria parasites develop within a
parasitophorous vacuole, which constitutes the interface between the parasite and its …

Despite global eradication efforts over the past century, malaria remains a devastating
public health burden, causing almost half a million deaths annually (WHO,). A detailed …

To gain insights into the molecular interactions of an intracellular pathogen and its host cell,
we studied the gene expression and chromatin states of human fibroblasts infected with the …

The successful navigation of malaria parasites through their life cycle, which alternates
between vertebrate hosts and mosquito vectors, requires a complex interplay of metabolite …

There is an important role for in vitro assays to better understand the initial steps of malaria
infection. In this section, we describe both microscopy-based and flow cytometry-based …

APOBEC3B, a gene involved in innate response, exhibits insertion–deletion polymorphism
across world populations. We observed the insertion allele to be nearly fixed in malaria …

Understanding the mechanisms of CD4 memory T cell (Tmem) differentiation in malaria is
critical for vaccine development. However, the metabolic regulation of CD4 Tmem …

Eliminating malaria parasites during the asymptomatic but obligate liver stages (LSs) of
infection would stop disease and subsequent transmission. Unfortunately, only a single …

Background DNA microarrays have been a valuable tool in malaria research for over a
decade but remain in limited use in part due their relatively high cost, poor availability, and …

Intracellular parasites reprogram host functions for their survival and reproduction. The
extent and relevance of parasite-mediated host responses in vivo remains poorly studied …