The most common treatments for infectious diseases target the invading pathogen. The
efficacy of such an approach may, however, be countered by the possibility of the …

Infection of liver cells by Plasmodium, the malaria parasite, is a clinically silent, obligatory
step of the parasite's life cycle. The authors studied the progression of Plasmodium infection …

Prior to infecting erythrocytes and causing malaria symptoms, Plasmodium parasites
undergo an obligatory phase of invasion and extensive replication inside their mammalian …

One target of protective immunity against the Plasmodium liver stage in BALB/c mice is
represented by the circumsporozoite protein (CSP), and mainly involves its recognition by …

P lasmodium parasites infect hepatocytes of their mammalian hosts and undergo obligate
liver stage development. The specific host cell attributes that are important for liver infection …

Highlights•Malaria sporozoites are highly selective for their hepatocyte host.•Malaria
parasites refine the host during their liver stage of development.•Novel approaches and …

The resilience of Plasmodium vivax, the most widely distributed malaria-causing parasite in
humans worldwide, is attributed to its ability to produce dormant liver forms known as …

“… the severe malaria situation has encouraged the scientific community to try to find new
drugs to tackle this disease. In fact, several nonprofit, public–private partnerships such as …

The liver stages of the malaria parasite are clinically silent and constitute ideal targets for
causal prophylactic drugs and vaccines. Cellular and molecular events responsible for liver …

Several protozoan parasites undergo a complex life cycle that alternates between an
invertebrate vector and a vertebrate host. Adaptations to these different environments by the …