Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Embedding of active substances in supramolecular systems has as the main goal to ensure
the controlled release of the active ingredients. Whatever the final architecture or entrapment …

The skin is a complex and multifunctional organ, in which the static versus dynamic balance
is responsible for its constant adaptation to variations in the external environment that is …

The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

Although biological activity is a key issue in developing a potent drug, other factors such as
solubility, absorption, partitioning, or biodegredation are equally important. Unfortunately …

Proteolysis targeting chimeras (PROTACs) are catalytic heterobifunctional molecules that
can selectively degrade a protein of interest by recruiting a ubiquitin E3 ligase to the target …

Conformational flexibility has been proposed to significantly affect drug properties outside
rule-of-5 (Ro5) chemical space. Here, we investigated the influence of dynamically exposed …

Many carbon-fixing bacteria rely on a CO2 concentrating mechanism (CCM) to elevate the
CO2 concentration around the carboxylating enzyme ribulose bisphosphate carboxylase …

The influence of physicochemical properties, including lipophilicity, H-bonding capacity and
molecular size and shape descriptors on brain uptake has been investigated using a …

Mathematical models of skin permeability play an important role in various fields including
prediction of transdermal drug delivery and assessment of dermal exposure to industrial …