[HTML][HTML] Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms

A Anjum, MD Yazid, M Fauzi Daud, J Idris… - International journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes
major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and …

Characterizing natural recovery after traumatic spinal cord injury

S Kirshblum, B Snider, F Eren, J Guest - Journal of neurotrauma, 2021 - liebertpub.com
The predominant tool used to predict outcomes after traumatic spinal cord injury (SCI) is the
International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), in …

Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

M Yu, Z Wang, D Wang, M Aierxi, Z Ma… - Journal of …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a medical condition that results from severe trauma to the central
nervous system; it imposes great psychological and economic burdens on affected patients …

Regenerative rehabilitation with conductive biomaterials for spinal cord injury

EA Kiyotake, MD Martin, MS Detamore - Acta biomaterialia, 2022 - Elsevier
The individual approaches of regenerative medicine efforts alone and rehabilitation efforts
alone have not yet fully restored function after severe spinal cord injury (SCI). Regenerative …

[HTML][HTML] The role of PI3K/Akt signalling pathway in spinal cord injury

CL Xiao, WC Yin, YC Zhong, JQ Luo, LL Liu… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex
pathological mechanisms that leads to sensory and motor dysfunction. The current treatment …

[HTML][HTML] Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury

F Gong, T Ge, J Liu, J Xiao, X Wu, H Wang… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) is the main cause of severe damage to the central nervous system
and leads to irreversible tissue loss and neurological dysfunction. Ferroptosis is a cell death …

Maltol promotes mitophagy and inhibits oxidative stress via the Nrf2/PINK1/Parkin pathway after spinal cord injury

Y Mao, J Du, X Chen, A Al Mamun… - Oxidative Medicine …, 2022 - Wiley Online Library
Spinal cord injury (SCI), a fatal disease in the central nervous system, is characteristic of
weak neuronal regeneration ability and complex pathological progress. Activation of …

Predicting outcomes after spinal cord injury

W Chay, S Kirshblum - Physical Medicine and Rehabilitation …, 2020 - pmr.theclinics.com
Jane Doe is a 66-year-old woman who was involved in a motor vehicle crash where she
sustained a T6 burst fracture. She underwent T5-7 laminectomy and posterior spinal fusion …

A multi-modal delivery strategy for spinal cord regeneration using a composite hydrogel presenting biophysical and biochemical cues synergistically

W Man, S Yang, Z Cao, J Lu, X Kong, X Sun, L Zhao… - Biomaterials, 2021 - Elsevier
Extensive tissue engineering studies have supported the enhanced spinal cord
regeneration by implantable scaffolds loaded with bioactive cues. However, scaffolds with …

[HTML][HTML] Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the …

C Li, T Qin, Y Liu, H Wen, J Zhao, Z Luo… - Frontiers in cell and …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a catastrophic event mainly involving neuronal apoptosis and
axonal disruption, and it causes severe motor and sensory deficits. Due to the complicated …