Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Alzheimer disease (AD) is the most common cause of dementia in older individuals (> 65
years) and has a long presymptomatic phase. Preventive therapies for AD are not yet …

Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

Fluoride is an important trace element in the living body. A suitable amount of fluoride has a
beneficial effect on the body, but disproportionate fluoride entering the body will affect …

Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause
of dementia among the elderly worldwide. Despite intense efforts to develop drugs for …

Sequence variations occurring in the gene encoding the triggering receptor expressed on
myeloid cells 2 (TREM 2) support an essential function of microglia and innate immunity in …

Alzheimer's disease (AD) is associated with deficiencies in cerebrovascular functions, eg
reduced cerebral blood flow and capillary amyloid angiopathy, both of which are evident …

Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of
caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and …