Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Improved MSC minimal criteria to maximize patient safety: a call to embrace tissue factor and hemocompatibility assessment of MSC products
The number of mesenchymal stromal/stem cell (MSC) therapeutics and types of clinical
applications have greatly diversified during the past decade, including rapid growth of poorly …
applications have greatly diversified during the past decade, including rapid growth of poorly …
Intravascular mesenchymal stromal/stem cell therapy product diversification: time for new clinical guidelines
Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …
Impact of cryopreservation and freeze-thawing on therapeutic properties of mesenchymal stromal/stem cells and other common cellular therapeutics
C Cottle, AP Porter, A Lipat, C Turner-Lyles… - Current stem cell …, 2022 - Springer
Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …
procedures–short “freeze-thawing”–are among the final steps in economically viable …
Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …
studied for their therapeutic potential across a wide range of diseases. In the preclinical …
Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation?
The essential physiological role of platelets in wound healing and tissue repair builds the
rationale for the use of human platelet derivatives in regenerative medicine. Abundant …
rationale for the use of human platelet derivatives in regenerative medicine. Abundant …
The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy
D García-Bernal, M García-Arranz… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) currently constitute the most frequently used cell type in
advanced therapies with different purposes, most of which are related with inflammatory …
advanced therapies with different purposes, most of which are related with inflammatory …
[HTML][HTML] Adverse events, side effects and complications in mesenchymal stromal cell-based therapies
DS Baranovskii, ID Klabukov… - Stem Cell …, 2022 - ncbi.nlm.nih.gov
Numerous clinical studies have shown a wide clinical potential of mesenchymal stromal
cells (MSCs) application. However, recent experience has accumulated numerous reports of …
cells (MSCs) application. However, recent experience has accumulated numerous reports of …
Mesenchymal stromal cells for enhancing hematopoietic engraftment and treatment of graft-versus-host disease, hemorrhages and acute respiratory distress …
O Ringdén, G Moll, B Gustafsson… - Frontiers in …, 2022 - frontiersin.org
Mesenchymal stromal cells (MSCs) possess profound immunomodulatory and regenerative
properties that are of clinical use in numerous clinical indications with unmet medical need …
properties that are of clinical use in numerous clinical indications with unmet medical need …
The translation of cell-based therapies: clinical landscape and manufacturing challenges
Cell-based therapies have the potential to make a large contribution toward currently unmet
patient need and thus effective manufacture of these products is essential. Many challenges …
patient need and thus effective manufacture of these products is essential. Many challenges …