The role of noncoding RNAs in Parkinson's disease: biomarkers and associations with pathogenic pathways
MC Kuo, SCH Liu, YF Hsu, RM Wu - Journal of biomedical science, 2021 - Springer
The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …
Uncovering the impacts of alternative splicing on the proteome with current omics techniques
M Reixachs‐Solé, E Eyras - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …
diversification through alternative splicing on the transcriptome. Moreover, the differential …
Human embryonic genome activation initiates at the one-cell stage
In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …
What can ribo-seq, immunopeptidomics, and proteomics tell us about the noncanonical proteome?
Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …
the human genome and proteome by illuminating thousands of noncanonical sites of …
Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours
Previous studies on paternal epigenetic inheritance have shown that sperm RNAs play a
role in this type of inheritance. The microinjection of sperm small noncoding RNAs into …
role in this type of inheritance. The microinjection of sperm small noncoding RNAs into …
Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells
Background Nonsense-mediated mRNA decay (NMD) is a eukaryotic, translation-
dependent degradation pathway that targets mRNAs with premature termination codons and …
dependent degradation pathway that targets mRNAs with premature termination codons and …
Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity
Animal venom systems have emerged as valuable models for investigating how novel
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …
Sequencing of individual barcoded cDNAs using Pacific Biosciences and Oxford Nanopore Technologies reveals platform-specific error patterns
Long-read transcriptomics require understanding error sources inherent to technologies.
Current approaches cannot compare methods for an individual RNA molecule. Here, we …
Current approaches cannot compare methods for an individual RNA molecule. Here, we …
mRNA vaccines: Why is the biology of retroposition ignored?
T Domazet-Lošo - Genes, 2022 - mdpi.com
The major advantage of mRNA vaccines over more conventional approaches is their
potential for rapid development and large-scale deployment in pandemic situations. In the …
potential for rapid development and large-scale deployment in pandemic situations. In the …
[HTML][HTML] A program of successive gene expression in mouse one-cell embryos
At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The
ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for …
ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for …