Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV
infection contributes to haematological abnormalities observed in HIV patients. The bone …

In sub-Saharan Africa (SSA) the burden of non-nucleoside reverse transcriptase inhibitor
(NNRTI) HIV drug resistance (HIVDR) has been high over the years. Therefore, in 2018 the …

Dolutegravir-based antiretroviral therapy (ART) has been scaled up in many developing
countries, including Ethiopia. However, subtype-dependent polymorphic differences might …

The increasing use of the integrase strand transfer inhibitor (INSTI) class for the treatment of
HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for …

One of the major factors contributing to HIV-1 drug resistance is suboptimal adherence to
combination antiretroviral therapy (cART). Currently, recommended cART for HIV-1 …

Background Transition to dolutegravir-based regimens in resource-limited settings (RLS)
requires prior understanding of HIV-1 integrase variants and conserved regions. Therefore …

Objectives HIV-1 integrase inhibitors are recommended as first-line therapy by WHO, though
efficacy and resistance data for non-B subtypes are limited. Two recent trials have identified …

A clear and precise report on synthetic methods for INSTIs and their intermediates are
provided in the present work. HIV Integrase strand transfer inhibitors (INSTIs), a class of …

Background Iran has recently included integrase (INT) inhibitors (INTIs) in the first‐line
treatment regimen in human immunodeficiency virus (HIV)-infected patients. However, there …

The human immunodeficiency virus type 1 (HIV-1) has several proteins of therapeutic
importance, many of which are currently used as drug targets in antiretroviral therapy …