Human embryonic stem cells (HESCs) are the in vitro descendants of the pluripotent inner
cell mass (ICM) of human blastocyst stage embryos. HESCs can be kept undifferentiated in …

Unprecedented developments in stem cell research herald a new era of hope and
expectation for novel therapies. However, they also present a major challenge for regulators …

Transplantation of human embryonic stem cells (hESC) into immune-deficient mice leads to
the formation of differentiated tumors comprising all three germ layers, resembling …

Background Human embryonic stem cells (hESC) should enable novel insights into early
human development and provide a renewable source of cells for regenerative medicine …

The potential for the formation of teratomas or other neoplasms is a major safety roadblock
to clinical application of pluripotent stem cell therapies. Preclinical assessment of the risk of …

Protocols based on the delivery of stem cells are currently applied in patients, showing
encouraging results for the treatment of articular cartilage lesions (focal defects …

Teratomas derived from human embryonic stem (hES) cells are unique among oncogenic
phenomena as they are polyclonal and develop from apparently normal cells,. A deeper …

Human embryonic stem cells (HESCs) and induced pluripotent stem cells (HiPSCs) offer an
immense potential as a source of cells for regenerative medicine. However, the ability of …

Alzheimer's disease (AD) is the most common progressive neurodegenerative disease
worldwide, but its cause remains unclear. Although a few drugs can provide temporary and …

Human pluripotent stem cells (hPSCs) are currently evaluated for clinical applications due to
their proliferation and differentiation capacities, raising the need to both assess and …