Recent genetic findings in schizophrenia and their therapeutic relevance
PJ Harrison - Journal of psychopharmacology, 2015 - journals.sagepub.com
Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …
[HTML][HTML] E proteins and ID proteins: helix-loop-helix partners in development and disease
LH Wang, NE Baker - Developmental cell, 2015 - cell.com
The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional
regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous …
regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous …
Mouse retinal cell atlas: molecular identification of over sixty amacrine cell types
Amacrine cells (ACs) are a diverse class of interneurons that modulate input from
photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively …
photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively …
Causal influences of neuroticism on mental health and cardiovascular disease
F Zhang, A Baranova, C Zhou, H Cao, J Chen, X Zhang… - Human genetics, 2021 - Springer
We investigated the relationship between neuroticism and 16 mental and 18 physical traits
using summary results of genome-wide association studies for these traits. LD score …
using summary results of genome-wide association studies for these traits. LD score …
[HTML][HTML] CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived …
P Wang, R Mokhtari, E Pedrosa, M Kirschenbaum… - Molecular autism, 2017 - Springer
Background CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …
[HTML][HTML] Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content
Abstract Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and
other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the …
other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the …
[HTML][HTML] Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer
F Zhou, H Gao, L Shang, J Li, M Zhang, S Wang… - Journal of Experimental …, 2023 - Springer
Background The incidence of colorectal cancer and cancer death rate are increasing every
year, and the affected population is becoming younger. Traditional Chinese medicine …
year, and the affected population is becoming younger. Traditional Chinese medicine …
Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions
The two main blood flow patterns, namely, pulsatile shear (PS) prevalent in straight
segments of arteries and oscillatory shear (OS) observed at branch points, are associated …
segments of arteries and oscillatory shear (OS) observed at branch points, are associated …
[HTML][HTML] TCF4-mediated Fuchs endothelial corneal dystrophy: Insights into a common trinucleotide repeat-associated disease
MP Fautsch, ED Wieben, KH Baratz… - Progress in retinal and …, 2021 - Elsevier
Fuchs endothelial corneal dystrophy (FECD) is a common cause for heritable visual loss in
the elderly. Since the first description of an association between FECD and common …
the elderly. Since the first description of an association between FECD and common …
[HTML][HTML] Tcf4 regulates synaptic plasticity, DNA methylation, and memory function
Human haploinsufficiency of the transcription factor Tcf4 leads to a rare autism spectrum
disorder called Pitt-Hopkins syndrome (PTHS), which is associated with severe language …
disorder called Pitt-Hopkins syndrome (PTHS), which is associated with severe language …