A poorly immunogenic murine colon cancer was used to investigate mechanisms of
antitumor immunity. Injection of tumor cells engineered by gene transfection to secrete IL-2 …

By generating two types of transgenic mice we have investigated how extrathymic events
can contribute to self tolerance. The major histocompatibility complex class I gene Kb was …

Immunologically privileged sites express Fas ligand (FasL), which protects them from attack
by activated T cells that express Fas and die upon contact with FasL. In an attempt to protect …

The mechanism by which T lymphocytes an? tolerized to self or foreign antigens is still
controversial. Clonal deletion is the major mechanism of tolerance for immature thymocytes; …

Efficient T cell activation is dependent on the intimate contact between antigen-presenting
cells (APCs) and T cells. The engagement of the B7 family of molecules on APCs with CD28 …

Fas ligand is believed to mediate immune privilege in a variety of tissues, including the eye,
testis, and a subset of tumors. We tested whether expression of Fas ligand on pancreatic …

Without a doubt, rodent models have been instrumental in describing pathways that lead to
pancreatic β-cell destruction, evaluating potential causes of type 1 diabetes and providing …

The factors that regulate pancreatic beta cell proliferation are not well defined. In order to
explore the role of murine placental lactogen (PL)-I (mPL-I) in islet mass regulationin vivo …

Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic p
cells, when? it is present at very high concentrations. We have produced thme lines of …

Invariant chain (li) is a nonpolymorphic glycoprotein that associates with major
histocompatibility complex class II molecules and has been shown to mediate several …