1993 represents the 100th anniversary of William Coley's first report of tumour regressions
induced by immune system activation in response to bacterial toxins. While many …

Parathyroid hormone-related protein (PTHrP) is produced by the pancreatic islet. It also has
receptors on islet cells, suggesting that it may serve a paracrine or autocrine role within the …

CD8+ T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to
generating T cell responses to tumor-associated antigens. We have made a T cell receptor …

T-CELL reactivity to the class II major histocompatibility complex IE antigen is associated
with T-cell antigen receptors containing the Vβ gene segments Vβ17a (ref. 1) and Vβ5 (ref …

A class I histocompatibility gene, H-2Kb, linked to the rat insulin promoter, is overexpressed
in the pancreatic β cells of transgenic mice. The mice, whether syngeneic or allogeneic to …

Tumor necrosis factor beta (TNF-beta)(lymphotoxin) may play an important role in the
immune response and pathologic inflammatory diseases. Insulitis is an important early step …

Viral infections in humans commonly result in the transient appearance of a variety of
autoantibodies and, in some patients, the development of autoimmune tissue injury and …

T cell tolerance to peripheral antigens is believed to result mainly from the inability of
parenchymal cells to present antigens in an immunogenic form due to the lack of expression …

ALTHOUGH convincing evidence has been obtained for the imposition of self-tolerance by
the intrathymic deletion of self-reactive T cells1–4, the development of tolerance to antigens …

Class II major histocompatibility complex (MHC) gene expression in the mouse is generally
limited to thymic epithelium and bone marrow-derived cells such as B lymphocytes and cells …