Transgenic animals
JW Gordon - International review of cytology, 1989 - Elsevier
Publisher Summary This chapter describes the mechanisms of foreign DNA integration in
transgenic mice. The fundamentals of gene regulation revealed by transgenic mice are …
transgenic mice. The fundamentals of gene regulation revealed by transgenic mice are …
Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked …
JWM Höppener, JS Verbeek, EJP De Koning… - Diabetologia, 1993 - Springer
Summary Type 2 (non-insulin-dependent) diabetes mellitus is characterised by
hyperglycaemia, peripheral insulin resistance, impaired insulin secretion and pancreatic …
hyperglycaemia, peripheral insulin resistance, impaired insulin secretion and pancreatic …
T cell reactivity to MHC molecules: immunity versus tolerance
J Sprent, EK Gao, SR Webb - Science, 1990 - science.org
The specificity of mature CD8+ and CD4+ T lymphocytes is controlled by major
histocompatibility complex (MHC) class I and class II molecules, respectively. The MHC …
histocompatibility complex (MHC) class I and class II molecules, respectively. The MHC …
Non-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen.
GJ Hämmerling, G Schönrich, F Momburg… - Immunological …, 1991 - europepmc.org
The studies described here reveal a surprising variety of non-deletional manifestations of
tolerance (anergy and unresponsiveness) in both the thymus and peripheral lymphoid …
tolerance (anergy and unresponsiveness) in both the thymus and peripheral lymphoid …
Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in …
Y Iwakura, S Saijo, Y Kioka… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
We recently reported on an inflammatory arthropathy resembling rheumatoid arthritis that
develops in high incidence among transgenic mice that carry the env-pX region of the …
develops in high incidence among transgenic mice that carry the env-pX region of the …
Immunologic tolerance: collaboration between antigen and lymphokines
GJV Nossal - Science, 1989 - science.org
Immunologic tolerance is the process whereby limits are placed on the degree to which
lymphocytes respond to an animal's inherent antigens. It is a quantitative rather than an …
lymphocytes respond to an animal's inherent antigens. It is a quantitative rather than an …
Expression of NGF in sympathetic neurons leads to excessive axon outgrowth from ganglia but decreased terminal innervation within tissues
The effects of nerve growth factor (NGF) on sympathetic axon growth were investigated by
generating transgenic mice in which the p subunit of NGF was expressed in sympathetic …
generating transgenic mice in which the p subunit of NGF was expressed in sympathetic …
[HTML][HTML] Induction of GVHD-like skin disease by passively transferred CD8+ T-cell receptor transgenic T cells into keratin 14-ovalbumin transgenic mice
A Shibaki, A Sato, JC Vogel, F Miyagawa… - Journal of investigative …, 2004 - Elsevier
To understand the mechanisms involved in immunological tolerance to skin-associated
antigens, we have developed transgenic (Tg) mice that express a model self-antigen …
antigens, we have developed transgenic (Tg) mice that express a model self-antigen …
Islet expression of interferon-α precedes diabetes in both the BB rat and streptozotocin-treated mice
X Huang, B Hultgren, N Dybdal, TA Stewart - Immunity, 1994 - cell.com
The mechanism (s) leading to p cell dysfunction in type I diabetes has not been defined. We
have investigated whether islet expression of IFNa could be a cause of the lesions that are …
have investigated whether islet expression of IFNa could be a cause of the lesions that are …
Transgenic mice with IA on islet cells are normoglycemic but immunologically intolerant
J Böhme, K Haskins, P Stecha, W Van Ewijk, M LeMeur… - Science, 1989 - science.org
Insulin-dependent diabetes mellitus (IDDM) is caused by a specific loss of the insulin-
producing beta cells from pancreatic Langerhans islets. It has been proposed that aberrant …
producing beta cells from pancreatic Langerhans islets. It has been proposed that aberrant …