Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Five decades ago, seminal studies positioned the brainstem locus coeruleus (LC)
norepinephrine (NE) system as a key substrate for the regulation of wakefulness and sleep …

Abnormally phosphorylated tau, an indicator of Alzheimer's disease, accumulates in the first
decades of life in the locus coeruleus (LC), the brain's main noradrenaline supply. However …

The clinical and pathophysiological correlates of locus coeruleus (LC) degeneration in
Alzheimer's disease (AD) could be clarified using a method to index LC integrity in vivo …

Previous studies have reported substantial involvement of the noradrenergic system in
Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become …

The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of
noradrenaline synthesis, has a major role in regulating autonomic function, arousal …

The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and
behavioral function, may play an important role healthy ageing and in neurodegenerative …

Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

Background Parkinson's disease (PD) causes a loss of neuromelanin‐positive,
noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor …