Health benefits and pharmacological properties of stigmasterol

S Bakrim, N Benkhaira, I Bourais, T Benali, LH Lee… - Antioxidants, 2022 - mdpi.com
Stigmasterol is an unsaturated phytosterol belonging to the class of tetracyclic triterpenes. It
is one of the most common plant sterols, found in a variety of natural sources, including …

[HTML][HTML] Anti-inflammatory and immunoregulatory effects of icariin and icaritin

Z Bi, W Zhang, X Yan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Inflammation and immunity dysregulation have received widespread attention in recent
years due to their occurrence in the pathophysiology of many conditions. In this regard …

Cancer resistance to immunotherapy: comprehensive insights with future perspectives

SS Said, WN Ibrahim - Pharmaceutics, 2023 - mdpi.com
Cancer immunotherapy is a type of treatment that harnesses the power of the immune
systems of patients to target cancer cells with better precision compared to traditional …

Pharmacological properties of trichostatin A, focusing on the anticancer potential: a comprehensive review

A Bouyahya, N El Omari, M Bakha, T Aanniz… - Pharmaceuticals, 2022 - mdpi.com
Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …

Molecular pathways and genomic landscape of glioblastoma stem cells: opportunities for targeted therapy

AM Hersh, H Gaitsch, S Alomari, D Lubelski, BM Tyler - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma stem cells are a unique population of tumor cells that
contribute to tumor growth, invasion, and resistance to chemotherapy and radiation therapy …

Natural Sources, Pharmacological Properties, and Health Benefits of Daucosterol: Versatility of Actions

N El Omari, I Jaouadi, M Lahyaoui, T Benali, D Taha… - Applied Sciences, 2022 - mdpi.com
Daucosterol is a saponin present in various natural sources, including medicinal plant
families. This secondary metabolite is produced at different contents depending on species …

Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms

A Lyubitelev, V Studitsky - International Journal of Molecular Sciences, 2023 - mdpi.com
Malignant tumors remain one of the main sources of morbidity and mortality around the
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …

Determination of Chemical Compounds and Investigation of Biological Properties of Matricaria chamomilla Essential Oils, Honey, and Their Mixture

A Qasem, H Assaggaf, D Montesano, Z Khalil… - Molecules, 2022 - mdpi.com
This exploratory investigation aimed to determine the chemical composition and evaluate
some biological properties, such as antioxidant, anti-inflammatory, antidiabetic, and …

[HTML][HTML] Molecular mechanisms underlying the clinical efficacy of panobinostat involve Stochasticity of epigenetic signaling, sensitization to anticancer drugs, and …

N El Omari, S Bakrim, A Khalid, AN Abdalla… - Biomedicine & …, 2023 - Elsevier
Panobinostat, also known as Farydak®, LBH589, PNB, or panobinostat lactate, is a
hydroxamic acid that has been approved by the Food and Drug Administration (FDA) for its …

Natural products modulating epigenetic mechanisms by affecting histone methylation/demethylation: Targeting cancer cells

D Dorna, A Grabowska… - British Journal of …, 2023 - Wiley Online Library
Many natural products can exert anticancer or chemopreventive activity by interfering with
the cellular epigenetic machinery. Many studies indicate the relevance of affecting DNA …