The role of cytochrome P450s in insect toxicology and resistance

R Nauen, C Bass, R Feyereisen… - Annual Review of …, 2022 - annualreviews.org
Insect cytochrome P450 monooxygenases (P450s) perform a variety of important
physiological functions, but it is their role in the detoxification of xenobiotics, such as natural …

Neonicotinoid insecticides: molecular targets, resistance, and toxicity

K Matsuda, M Ihara, DB Sattelle - Annual review of …, 2020 - annualreviews.org
Neonicotinoids have been used to protect crops and animals from insect pests since the
1990s, but there are concerns regarding their adverse effects on nontarget organisms …

Glyphosate impairs collective thermoregulation in bumblebees

A Weidenmüller, A Meltzer, S Neupert, A Schwarz… - Science, 2022 - science.org
Insects are facing a multitude of anthropogenic stressors, and the recent decline in their
biodiversity is threatening ecosystems and economies across the globe. We investigated the …

Global trends in bumble bee health

SA Cameron, BM Sadd - Annual review of entomology, 2020 - annualreviews.org
Bumble bees (Bombus) are unusually important pollinators, with approximately 260 wild
species native to all biogeographic regions except sub-Saharan Africa, Australia, and New …

[HTML][HTML] Insights into the microbial degradation and biochemical mechanisms of neonicotinoids

S Pang, Z Lin, W Zhang, S Mishra, P Bhatt… - Frontiers in …, 2020 - frontiersin.org
Neonicotinoids are derivatives of synthetic nicotinoids with better insecticidal capabilities,
including imidacloprid, nitenpyram, acetamiprid, thiacloprid, thiamethoxam, clothianidin, and …

[HTML][HTML] Pesticide Exposure and Effects on Non-Apis Bees

NE Raine, M Rundlöf - Annual Review of Entomology, 2024 - annualreviews.org
Bees are essential pollinators of many crops and wild plants, and pesticide exposure is one
of the key environmental stressors affecting their health in anthropogenically modified …

Phylogenomic and functional characterization of an evolutionary conserved cytochrome P450-based insecticide detoxification mechanism in bees

J Haas, A Hayward, B Buer… - Proceedings of the …, 2022 - National Acad Sciences
The regulatory process for assessing the risks of pesticides to bees relies heavily on the use
of the honeybee, Apis mellifera, as a model for other bee species. However, the validity of …

Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila

F Martelli, Z Zhongyuan, J Wang… - Proceedings of the …, 2020 - National Acad Sciences
Declining insect population sizes are provoking grave concern around the world as insects
play essential roles in food production and ecosystems. Environmental contamination by …

[HTML][HTML] Species sensitivity to toxic substances: Evolution, ecology and applications

D Spurgeon, E Lahive, A Robinson, S Short… - Frontiers in …, 2020 - frontiersin.org
Because it is only possible to test chemicals for effects on a restricted range of species and
exposure scenarios, ecotoxicologists are faced with a significant challenge of how to …

Divergent amplifications of CYP9A cytochrome P450 genes provide two noctuid pests with differential protection against xenobiotics

Y Shi, Q Liu, W Lu, J Yuan, Y Yang… - Proceedings of the …, 2023 - National Acad Sciences
Here, we provide mechanistic support for the involvement of the CYP9A subfamily of
cytochrome P450 monooxygenases in the detoxification of host plant defense compounds …