Heart failure (HF) is a major health-care problem and the prognosis of affected patients is
poor. HF often coexists with a number of comorbidities of which declining renal function is of …

Vascular calcification (VC) is highly prevalent in aging, diabetes mellitus, and chronic kidney
disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD …

Objectives This study sought to assess if clinical phenogroups differ in comprehensive
biomarker profiles, cardiac and arterial structure/function, and responses to spironolactone …

During the last two decades, the potential impact of vitamin D on the risk of cardiovascular
disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD …

Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on
target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co …

The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

Background In chronic kidney disease (CKD), serum concentrations of fibroblast growth
factor 23 (FGF23) increase progressively as glomerular filtration rate declines, while renal …

Inorganic phosphate (Pi) is essential for signal transduction and cell metabolism, and is also
an essential structural component of the extracellular matrix of the skeleton. Pi is sensed in …

Inorganic phosphate (Pi) is an abundant element in the body and is essential for a wide
variety of key biological processes. It plays an essential role in cellular energy metabolism …

Recent advances in our understanding of the association between vitamin D and anemia
suggest that maintenance of sufficient vitamin D status may be important in preventing …