Intravitreal antivascular endothelial growth factor (anti-VEGF) treatment has drastically
improved the visual and anatomical outcomes in patients with diabetic macular edema …

Diabetic retinopathy is a major retinal disorder and a leading cause of blindness. Diabetic
macular edema (DME) is an ocular complication in patients with diabetes, and it can impair …

As the only blood vessels that can directly be seen in the whole body, pathological changes
in retinal vessels are related to the metabolic state of the whole body and many systems …

Bioaffinity drug screening strategies have gained popularity in preclinical and clinical drug
discovery for natural products, small molecules and antibodies owing to their superior …

Therapeutic fusion proteins are a class of hybrid constructs that combine distinct
biomolecules into a single platform with the additive effects of the components. The ability to …

Vascular endothelial growth factors (VEGF), Vascular endothelial growth factor receptors
(VEGFR) and their downstream signaling pathways are promising targets in anti-angiogenic …

The blood–brain barrier (BBB) is a physiological barrier maintaining a specialized brain
micromilieu that is necessary for proper neuronal function. Endothelial tight junctions and …

Purpose To assess the 12 month outcomes of intravitreal faricimab (IVF) in treatment-
resistant diabetic macular edema (DME) recalcitrant to intravitreal aflibercept (IVA). Methods …

Diabetic macular edema (DME) is a common sight-threatening complication of diabetic
retinopathy (DR) and the leading cause of severe visual impairment among the working-age …

The degeneration of intervertebral discs is strongly associated with the occurrence of
pyroptosis in nucleus pulposus (NP) cells. This pyroptosis is characterized by abnormal …