Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

The complement system consists of a network of plasma and membrane proteins that
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …

In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …

Biological molecules are increasingly becoming a part of the therapeutics portfolio that has
been either recently approved for marketing or those that are in the pipeline of several …

The complement system consists of a tightly regulated network of proteins that play an
important role in host defense and inflammation. Complement activation results in …

The complement system is important for cellular integrity and tissue homeostasis.
Complement activation mediates the removal of microorganisms and the clearance of …

Osteoarthritis, characterized by the breakdown of articular cartilage in synovial joints, has
long been viewed as the result of'wear and tear'. Although low-grade inflammation is …

The complement system plays an important role in the innate and acquired immune
response against pathogens. It consists of more than 30 proteins found in soluble form or …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …