Redifferentiation of radioiodine-refractory thyroid cancers
C Buffet, J Wassermann, F Hecht… - Endocrine-Related …, 2020 - erc.bioscientifica.com
The management of radioiodine refractory thyroid cancers (RAIR TC) is challenging for the
clinician. Tyrosine kinase inhibitors classically prescribed in this setting can fail due to …
clinician. Tyrosine kinase inhibitors classically prescribed in this setting can fail due to …
The complex regulation of NIS expression and activity in thyroid and extrathyroidal tissues
G Riesco-Eizaguirre, P Santisteban… - Endocrine-Related …, 2021 - erc.bioscientifica.com
The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
active iodide transport into the thyroid gland and into several extrathyroidal tissues. NIS …
active iodide transport into the thyroid gland and into several extrathyroidal tissues. NIS …
Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion
As the most abundant liver-specific microRNA, miR-122 is involved in diverse aspects of
hepatic function and neoplastic transformation. Our previous study showed that miR-122 …
hepatic function and neoplastic transformation. Our previous study showed that miR-122 …
Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets
C Spitzweg, KC Bible, LC Hofbauer… - The lancet Diabetes & …, 2014 - thelancet.com
Approximately 30% of patients with advanced, metastatic differentiated thyroid cancer have
radioiodine-refractory disease, based on decreased expression of the sodium iodide …
radioiodine-refractory disease, based on decreased expression of the sodium iodide …
The sodium iodide symporter (NIS) as an imaging reporter for gene, viral, and cell-based therapies
AR Penheiter, SJ Russell, SK Carlson - Current gene therapy, 2012 - ingentaconnect.com
Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …
invasive imaging of reporter gene products to reveal the distribution of molecular …
The associations between thyroid-related hormones and the risk of thyroid cancer: An overall and dose-response meta-analysis
Z Wang, Y Lin, Y Jiang, R Fu, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Objective Thyroid cancer (TC) is one of the most common malignant tumours of the
endocrine system. Thyroid-stimulating hormone (TSH) is known as being a risk factor for TC …
endocrine system. Thyroid-stimulating hormone (TSH) is known as being a risk factor for TC …
[HTML][HTML] Flavonoid rutin increases thyroid iodide uptake in rats
CFL Gonçalves, MCS dos Santos, MG Ginabreda… - PloS one, 2013 - ncbi.nlm.nih.gov
Thyroid iodide uptake through the sodium-iodide symporter (NIS) is not only an essential
step for thyroid hormones biosynthesis, but also fundamental for the diagnosis and treatment …
step for thyroid hormones biosynthesis, but also fundamental for the diagnosis and treatment …
miRNA-106a directly targeting RARB associates with the expression of Na+/I− symporter in thyroid cancer by regulating MAPK signaling pathway
CT Shen, ZL Qiu, HJ Song, WJ Wei, QY Luo - Journal of Experimental & …, 2016 - Springer
Background Serum miRNAs profiles between papillary thyroid carcinoma (PTC) patients
with non-131 I and 131 I-avid lung metastases are differentially expressed. These miRNAs …
with non-131 I and 131 I-avid lung metastases are differentially expressed. These miRNAs …
Analysis of NIS plasma membrane interactors discloses key regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN pathway with potential implications for radioiodine re …
Simple Summary The presence of the sodium–iodide symporter (NIS) at the plasma
membrane (PM) of differentiated thyroid cancer (DTC) cells is required for the successful use …
membrane (PM) of differentiated thyroid cancer (DTC) cells is required for the successful use …
Cleavage efficiency of the intramembrane protease γ-secretase is reduced by the palmitoylation of a substrate's transmembrane domain
M Assfalg, G Guener, SA Mueller… - Faseb …, 2022 - epub.ub.uni-muenchen.de
The intramembrane protease gamma-secretase has broad physiological functions, but also
contributes to Notch-dependent tumors and Alzheimer's disease. While gamma-secretase …
contributes to Notch-dependent tumors and Alzheimer's disease. While gamma-secretase …