c‐Src was the first protein kinase to be described as capable of phosphorylating tyrosine
residues. Subsequent identification of other tyrosine‐phosphorylating protein kinases with a …

Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are
involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive
impairment that currently is uncurable. Previous study shows that trilobatin (TLB), a naturally …

Due to the increased crewed spaceflights in recent years, it is vital to understand how the
space environment affects human health. A lack of gravitational force is known to risk …

Activation of the NLRP3 inflammasome results in caspase 1 cleavage, which subsequently
leads to IL-1 β and IL-18 secretion, as well as pyroptosis, and aberrant activation of the …

Alzheimer's disease (AD) is the most common neurodegenerative disease that currently
lacks available effective therapy. Thus, identifying novel molecular biomarkers for diagnosis …

Innate immune activation has been shown to reduce the severity of nervous system
disorders such as brain ischemia and traumatic brain damage. Macrophage-colony …

Abstract Background Copper (Cu) is an essential metal mediating a variety of vital biological
reactions with its redox property. Its dyshomeostasis has been associated with accelerated …

A variety of Alzheimer's disease (AD) mouse models has been established and
characterized within the last decades. To get an integrative view of the sophisticated …

Summary Late-Onset Alzheimer's Disease (LOAD) results from a complex pathological
process influenced by genetic variation, aging and environment factors. Genetic …