Sažetak The complex process of biological aging, as an intrinsic feature of living beings, is
the result of genetic and, to a greater extent, environmental factors and time. For many of the …

Complex structural and functional changes occur in the arterial system with advancing age.
The aged artery is characterized by changes in micro RNA expression patterns, autophagy …

Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …

Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …

Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular
diseases in ageing population. Although ECs rely on glycolysis for energy production, little is …

Dormancy occurs when cells remain viable but stop proliferating. When most of a cancer
population undergoes this phenomenon, the result is called tumor dormancy, and when a …

Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …

Body weight is a component of the mechanical theory of OA (osteoarthritis) pathogenesis.
Obesity was also found to be a risk factor for digital OA involving non-weight-bearing joints …

Aging is a natural process associated with declined organ function and higher susceptibility
to developing chronic diseases. A systemic single‐cell type‐based study provides a unique …