Myelin management by the 18.5‐kDa and 21.5‐kDa classic myelin basic protein isoforms

G Harauz, JM Boggs - Journal of neurochemistry, 2013 - Wiley Online Library
The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass
from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in …

MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis

KA Vassall, VV Bamm, G Harauz - Biochemical Journal, 2015 - portlandpress.com
The classic isoforms of myelin basic protein (MBP, 14–21.5 kDa) are essential to formation
of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The …

Proline: the distribution, frequency, positioning, and common functional roles of proline and polyproline sequences in the human proteome

AA Morgan, E Rubenstein - PloS one, 2013 - journals.plos.org
Proline is an anomalous amino acid. Its nitrogen atom is covalently locked within a ring, thus
it is the only proteinogenic amino acid with a constrained phi angle. Sequences of three …

Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis

BS Shin, T Katoh, E Gutierrez, JR Kim… - Nucleic Acids …, 2017 - academic.oup.com
Whereas ribosomes efficiently catalyze peptide bond synthesis by most amino acids, the
imino acid proline is a poor substrate for protein synthesis. Previous studies have shown that …

The effects of threonine phosphorylation on the stability and dynamics of the central molecular switch region of 18.5-kDa myelin basic protein

KA Vassall, K Bessonov, M De Avila, E Polverini… - PloS one, 2013 - journals.plos.org
The classic isoforms of myelin basic protein (MBP) are essential for the formation and
maintenance of myelin in the central nervous system of higher vertebrates. The protein is …

[PDF][PDF] Glyphosate pathways to modern diseases VI: Prions, amyloidoses and autoimmune neurological diseases

A Samsel, S Seneff - J. Biol. Phys. Chem, 2017 - thinktwice.com
Usage of the herbicide glyphosate on core crops in the USA has increased exponentially
over the past two decades, in step with the exponential increase in autoimmune diseases …

Environmentally friendly fluoroquinolone derivatives with lower plasma protein binding rate designed using 3D-QSAR, molecular docking and molecular dynamics …

Y Hou, Y Zhao, Y Li - … Journal of Environmental Research and Public …, 2020 - mdpi.com
Comparative molecular similarity index analysis (CoMSIA) was used to establish a three-
dimensional quantitative structure–activity relationship (3D-QSAR) model with structural …

Strategies to control human health risks arising from antibiotics in the environment: molecular modification of qns for enhanced plant–microbial synergistic degradation

P Sun, W Zhao - International Journal of Environmental Research and …, 2021 - mdpi.com
In the present work, a comprehensive screening and evaluation system was established to
improve the plant–microbial synergistic degradation effects of QNs. The study included the …

Neuropilin-1 peptide-like ligands with proline mimetics, tested using the improved chemiluminescence affinity detection method

AK Puszko, P Sosnowski, D Tymecka, F Raynaud… - …, 2019 - pubs.rsc.org
Many reports have suggested that NRP-1 acts as a co-receptor for VEGF-A165 and boosts
tumour growth and metastasis. This NRP-1, due to its important role in tumour progression …

Multiscale molecular dynamics simulations of sodium dodecyl sulfate micelles: from coarse-grained to all-atom resolution

G Roussel, C Michaux, EA Perpète - Journal of molecular modeling, 2014 - Springer
Sodium dodecyl sulfate (SDS) is a well-known anionic detergent widely used in both
experimental and theoretical investigations. Many molecular dynamics (MD) simulation have …